منابع مشابه
Carbohydrate-induced conformational change in concanavalin A.
Carbohydrate-binding proteins occur widely in the plant kingdom. These proteins, commonly derived from seeds, are called phytohemagglutiuins or lectins (reviewed by Sharon and Lis’). It has become increasingly apparent that lectins can serve as probes for carbohydrate structure and function. The jack-bean lectin, namely, concanavalin A (con A), has received considerable attention because of its...
متن کاملConcanavalin-A reports agonist-induced conformational changes in the intact GluR6 kainate receptor.
The agonist-binding domain of ionotropic glutamate receptors (iGluRs) has recently been crystallized as two polypeptide chains with a linker region. Although work on the structure of this isolated ligand-binding core has been invaluable, there is debate over how it relates to conformations adopted by intact receptors. iGluR crystals are proposed to represent the activated state as their degree ...
متن کاملA Study of the Oxidation-Induced Conformational and Functional Changes in Neuroserpin
Neuroserpin, a member of the Serine Proteinase Inhibitor (Serpin) superfamily, is known to be a neuroprotective factor in the focal ischemic stroke followed by reducing the microglial activation. Neuroserpin is a protein rich of methionine residues that can scavenge the free radical species which may increase its neuroprotective effect. On the other hand, the oxidative modifications of the amin...
متن کاملChanges in concanavalin A-reactive proteins in inflammatory disorders.
Quantitative changes of concanavalin A (Con A)-reactive proteins in serum samples obtained from rats with induced inflammation and from patients with inflammatory and autoimmune diseases were examined by use of lectin blots. Treatment of rats with a single dose of fermented yeast to induce inflammation caused an extensive increase in Con A-reactivity. These changes were time dependent and were ...
متن کاملBINDING SITES ON CONCANAVALIN A 399 Concanavalin
Equilibrium dialysis of concanavalin A against methyl c¢-D-mannopyranoside and methyl C¢-D-glucopyranoside conducted at 2 ° in the presence of I M NaC1 showed that concanavalin A is bivalent. A SCATCHARD plot of the data obtained gave straight lines for both sugars with observed association constants (K') of 1. 4. lO 4 1/mole for methyl ,¢-D-mannopyranoside and o.3" IO 4 1/mole for methyl ~¢-D-...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1971
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)62095-2